Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie
 

Publications Featuring upcyte® Cells

2023

Kaden et al. – Generation & characterization of expandable human liver sinusoidal endothelial cells and their application to assess hepatotoxicity in an advanced in vitro liver model
Dynamic42 GmbH, Jena, Germany
Upcyte technologies GmbH - CliniSciences Group, Hamburg, Germany

2022

Romaldini et al. – Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte® Hepatocytes
D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genoa, Italy; Electron Microscopy Facility, Istituto Italiano di Tecnologia, Genoa, Italy; Unit of Molecular Oncology and Angiogenesis, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

2020

Korn et al. – Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog
Sanofi-Aventis (Frankfurt, Germany)
Petrov et al. – Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)
López-Riera et al. – A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)
Martínez-Sena et al. – The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)

2019

Nischalke et al. – The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu
University Hospital of Bonn (Bonn, Germany)
Tolosa et al. – Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)
Schulz et al. – NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
Brandenburg University of Technology Cottbus-Senftenberg (Senftenberg, Germany)

2018

Fernández-Murga et al. – Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)
Petrov et al. – Predicting drug-induced cholestasis: preclinical models
Instituto de Investigación Sanitaria La Fe (IIS La Fe, Valencia, Spain)
Schaefer et al. – Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes
Boehringer Ingelheim (Biberach, Germany & Kobe, Japan)
Gaitantzi et al. – Di (2-Ethylhexyl) Phthalate and Its Role in Developing Cholestasis: An In Vitro Study on Different Liver Cell Types
Department of Medicine II, Medical Faculty Mannheim, Heidelberg University (Mannheim, Germany)

2017

Johaennig et al. – The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology & University of Tuebingen (Tuebingen & Stuttgart, Germany)

2016

Rolvering et al. – Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
University of Luxembourg (Belvaux, Luxembourg)
Tolosa et al. – human upcyte hepatocytes: characterization of the hepatic phenotype and evaluation for acute and long term hepatotoxicity routine testing
University of Valencia (Valencia, Spain)
Schaefer et al. – upcyte human hepatocytes: a potent in vitro tool for the prediction of hepatic clearance of metabolically stable compounds
Boehringer Ingelheim (Biberach, Germany)

2015

Levy et al. – Long-term culture and expansion of primary human hepatocytes – Nature Biotech
The Hebrew University of Jerusalem (Israel)
Ramachandran et al. – in vitro generation of functional liver organoid-like structures using adult human cells
University of Heidelberg/Mannheim & Wuerzburg (Germany), University of Tromso (Norway)
Deuschle et al. – the nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein
Phenex Pharmaceuticals AG (Heidelberg, Germany) // Synovo GmbH (Tuebingen, Germany)
Ramachandran et al. – applicability of second-generation upcyte® human hepatocytes for use in CYP inhibition and induction studies
 
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